In another 10-week study, 72 people took 300 mg of Cissus quadrangularis daily. It also improved fasting blood sugar, triglycerides, and total and LDL (bad) cholesterol levels ( 11). This treatment significantly decreased body weight and belly fat, regardless of diet. In an 8-week study, 123 people took 1,028 mg of Cissus quadrangularis daily, as well as a combination of other supplements, including green tea, selenium, and chromium. Some research shows that Cissus quadrangularis may help prevent metabolic syndrome by improving several of these conditions. These conditions include excess belly fat, high blood pressure and blood sugar, and increased cholesterol or triglyceride levels ( 10). Metabolic syndrome is a cluster of conditions that can increase your risk of heart disease, stroke, and diabetes. However, human studies in this area are lacking, and more research is needed to investigate the potential benefits of Cissus quadrangularis on joint health. One 8-week study in 29 men with chronic joint pain found that taking 3,200 mg of Cissus quadrangularis daily significantly reduced exercise-induced joint pain ( 7).Īnother study observed that feeding Cissus quadrangularis extract to rats reduced joint swelling and decreased several markers of inflammation, indicating that it may help treat arthritis ( 8).įurthermore, a study in rats with arthritis noted similar findings, reporting that Cissus quadrangularis was more effective at reducing swelling than common medications used to treat rheumatoid arthritis and decrease inflammation ( 9). May reduce joint pain and swellingĬissus quadrangularis has been shown to help reduce joint pain and relieve symptoms of arthritis, a condition characterized by swollen, stiff joints. Similarly, a 3-month study in 60 people showed that taking 1,200 mg of Cissus quadrangularis daily promoted fracture healing and increased levels of a specific protein required for bone formation ( 6). It also appeared to reduce pain and swelling ( 5). What’s more, a study in 9 people observed that taking 500 mg of Cissus quadrangularis 3 times per day for 6 weeks helped speed the healing of fractured jaw bones. In fact, an 11-week study found that feeding Cissus quadrangularis to mice with osteoporosis helped prevent bone loss by altering levels of certain proteins involved in bone metabolism ( 4). May promote bone healthĪnimal and human studies have found that Cissus quadrangularis may help reduce bone loss, speed the healing of fractures, and help prevent conditions like osteoporosis. Here are the top science-based benefits of Cissus quadrangularis. Although Cissus quadrangularis is used to treat a number of health conditions, only a few of these uses are backed by research.

Devils backbone plant.